"Pump-controlled release tablets production process"

On March 1, 2003, an important project appraisal meeting was held at Tsinghua University, organized by the Beijing Tsinghua Institute of Industrial Development Incubator. The event focused on the technological achievements of Peking Pharmaceutical Co., Ltd. regarding the "osmotic pump controlled release tablets" project, which had successfully completed its research and development phase. During the meeting, the company presented a detailed report on the production technology for osmotic pump tablets, along with supporting documents such as drug inspection reports, user feedback, scientific and technological review reports, and materials from the State Drug Administration. After thorough discussions, the expert panel highly praised the project's scientific and technological advancements. Beijing Zhong Hui Pharmaceutical Co., Ltd. made significant progress in the development of osmotic pump controlled release tablets, conducting in-depth studies on various drugs with different physicochemical properties and formulation types. They established a comprehensive technology platform for osmotic pump preparation and developed the capability to produce a wide range of formulations. Their innovation included advanced formulas containing high-suspension agents, swelling agents, solubilizers, and efficient disintegrants, allowing them to create highly suspended single-agent osmotic pump tablets. This process simplified manufacturing, improved quality control, and significantly reduced costs, giving the product a strong market advantage. Notably, this technology had not been previously reported domestically or internationally. A key achievement of the project was the first successful preparation of a controlled-release formulation for traditional Chinese medicine: Cyclovirobuxine D osmotic pump tablets. These tablets released the drug at a constant rate over 24 hours, demonstrating excellent controlled-release characteristics in animal studies. Additionally, the company developed a new high-speed laser drilling machine, capable of achieving high precision in single-hole drilling and double-sided penetration, providing a solid foundation for large-scale production of osmotic pump tablets. In September 2002, Beijing Zhong Hui Pharmaceutical Co., Ltd. received a new drug certificate and production approval from the State Drug Administration for its salbutamol sulfate osmotic pump tablets. The company is currently constructing a controlled-release preparation production base in the Yongfeng High-tech Industrial Zone of Zhongguancun Science Park, with plans to complete the facility by June 2003. Once operational, this project will fill a gap in the domestic osmotic pump technology industry and generate substantial social and economic benefits. Experts highlighted that the "osmotic pump controlled release tablets production technology" project demonstrated high technical difficulty and a strong starting point. The development of highly suspended single-chamber single-layer osmotic pump technology for insoluble drugs has reached international standards. The high-speed laser drilling machine, a key piece of equipment, is among the best in China. Experts recommended that the government and social funds support further development of the osmotic pump technology platform, especially in combination with traditional Chinese medicine, to advance slow-controlled release formulations. This could lead to new innovations in the pharmaceutical industry and contribute to the development of new materials and technologies.

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